Liver Stiffness and Risk of Recurrence after Liver Resection for HCC

Introduction: Liver resection(LR) is a curative treatment for hepatocellular carcinoma(HCC) in selected patients context of organ shortage, but the rate recurrence remains high. Our objective was to propose predictive score after LR, based on preoperative factors. Methods: Retrospective monocentric study including who underwent LR HCC between 2015-2018 with AFP score<2 measurement liver stiffness. Recurrence were defined as appearance imaging confirmed at our tumor board. We developed using Cox univariate regression and multivariate analyzis combination plot, optimal thresholds(ROC curves) tested it validation cohort Bootstrap method. Results: 66 HCC. Median meld 8, 54% had an 0 88% single nodule. After average follow-up 40 months, 45.5%. Four variables significantly impacted risk ROC curves allowed select cut off: age >72 years (95% CI1.02-1.14, p=0.003), stiffness >11.2 kPa CI1.02-1.09, p<0.01), INR >1.2 CI2.42-1563, p<0.01) maximum diameter >2.7cm CI1.57-3.23, p<0.01). By assigning one point per positive item, <2 higher recurrence-free survival than those ≥2 (median DFS: 65 months vs. 44 p<0.0001). Conclusion: have identified 4 factors resection, highlighting role This could assist physicians patient selection LT.